Anxiety

Researchers have found that 2-AG (2-arachidonoylglycerol ), a molecule produced by the brain which can activate the body’s cannabinoid receptors, is able to protect the brain against stress by reducing connections between two brain regions which heighten anxiety. Published in the neuroscience research journal Neuron, the results may help scientists to better understand why many people find cannabis to be an effective treatment.

• CBD as an anxiolytic drug
• Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa
• CBD reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients
• Neural basis of anxiolytic effects of CBD in generalized social anxiety disorder
• Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation
• Effects of CBD on regional cerebral blood flow
• The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1Areceptors
• The anxiolytic effect of CBD on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
• Plant-based medicines for anxiety disorders, part 2
• A systematic review of plant-derived natural compounds for anxiety disorders
• The Endocannabinoid System and Anxiety
• CBD regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders
• Effect of prior footshock stress and Δ9-tetrahydrocannabinol, cannabidiolic acid, and cannabidiol on anxiety-like responding in the light-dark emergence test in rats
• The effectiveness of Cannabidiol Oil for Pediatric Anxiety and Insomnia as Part of Posttraumatic Stress Disorder: A Case Report.
• CBD Does Not Dampen Responses to Emotional Stimuli in Healthy Adults
• Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects
• Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa
• Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
• Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
• Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders
• Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives
• Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation
• Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors
• Effects of Cannabidiol (CBD) on Regional Cerebral Blood
• Effects of ipsapirone and cannabidiol on human experimental anxiety
• Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
• Medical cannabis and mental health: A guided systematic review
• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
• Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice
• Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence
• Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system